PTBP1 and Parkinson disease: Recently, Zhou et al. (2020) reported an efficient conversion of Müller glia into retinal ganglion cells (RGCs) by downregulation of the polypyrimidine tract-binding protein 1 (Ptbp1), employing an in vivo viral delivery and the CRISPR-Cas13d (CasRx), in this research was proven induction of neurons with dopaminergic features in the striatum that contrasted motor defects in a PD mouse model (Zhou et al., 2020).