GMF is a growth and differentiation factor majorly expressed in CNS; it has been indicated as a pro-inflammatory protein playing a central role in neuroinflammatory and neurodegenerative diseases such as AD, PD, and multiple sclerosis (MS) (Kempuraj et al., 2018a; Kempuraj et al., 2018b; Fan et al., 2018; Raikwar et al., 2019). The gene discussed is GMFB; the disease is Alzheimer disease.