Additionally, δEF1 family proteins (δEF1/zinc finger E-box binding homeobox 1 and Smad interacting protein-1/zinc finger E-box binding homeobox 2), key regulators of epithelial-mesenchymal transition (EMT), inhibit RGS16 expression and promotebreast cancer cell invasion, suggesting that low RGS16 expression may contribute to the promotion of cancer cell motility by δEF1 family proteins (Hoshi et al., 2016). The gene discussed is ZEB2; the disease is cancer.