RGS16 and RGS8 are expressed in embryonic pancreatic progenitor and endocrine cells and disappear in adults; however they are reactivated in type I and II diabetes models, which suggests that the RGS16 and RGS8 proteins may become a novel target for further treatment of diabetes (Villasenor et al., 2010). Here, RGS16 is linked to diabetes mellitus.