RGS16 and Patent ductus arteriosus: Expression of RGS16- green fluorescent protein (GFP), which inhibits Gi/q-coupled GPCRs, negatively regulates pancreatic ductal adenocarcinoma (PDA) progression and can be used for rapid preclinical in vivo validation of novel chemotherapeutic agents targeting early lesions in patients at high risk for successful resection or progression to PDA.