This disagreement may be due to forced GSDMD overexpression, which can reverse gastric cancer cell proliferation by inactivating the ERK, STAT3, and PI3K/AKT pathways, and then inhibiting the Cyclin A2/CDK-2 complex to arrest the S/G2 phase transition (Wang et al., 2018). This evidence concerns the gene CCNA2 and gastric cancer.