MYC and autosomal dominant polycystic kidney disease: In ADPKD, mTOR and c-Myc are consistently upregulated in PKD kidneys and repress oxidative metabolism, markedly enhance glycolytic flux (through upregulation of glucose transporters and the key glycolytic enzymes HK and PFK) and lactic acid production and export (through upregulation of LDH-A and monocarboxylic acid transporter 4, MCAT4 (Rowe et al., 2013; Podrini et al., 2020)).