Furthermore, CREB has been implicated in metabolic reprogramming by targeting some critical glycolytic enzymes and PKA/CREB signaling has been found to drive metabolic reprogramming in some cancers (e.g., hepatocellular and prostatic carcinomas (Figure 4) (Moon et al., 2011; Sun et al., 2021)). This evidence concerns the gene CREB1 and prostate carcinoma.