PKHD1 and cyst: Inhibition of glutaminase-1, which transforms glutamine into glutamate then catabolized into α-ketoglutarate, slowed cyst growth in Aqp2-Cre;Pkd1flx/flx but not in Pkhd1-Cre;Pkd1flx/flx mice (Flowers et al., 2018; Soomro et al., 2018).