PKD2 and Hepatic cysts: In contrast, mice with a conditional PC2/AC6 double knockout have no decrease in liver cyst volume compared to Pkd2 knockout alone, whereas AC5 siRNA and/or inhibitors inhibit cAMP production and pERK1/2 expression by PC2 deficient cholangiocytes, growth of PC2 deficient biliary organoids, and liver cystic area and cell proliferation in conditional Pkd2 knockout mice.