Treatment of Pkd1 knockout mice with the CFTR regulator VX-809 (Lumacaftor) increased the localizations of CFTR in the basolateral membrane of cyst lining cells and those of the sodium proton exchanger 3 and the epithelial sodium channel in the apical membrane, thus promoting net resorption of cyst fluid, reducing cyst growth, and protecting kidney function (Yanda et al., 2018). Here, CFTR is linked to cyst.