Inhibition of SIRT1 with a pan-sirtuin inhibitor nicotinamide and a specific inhibitor EX-527 slowed cyst growth in three PKD mouse models (embryonic model Pkd1−/−, Pkd1flox/flox:Ksp-Cre, and hypomorphic Pkd1nl/nl). The gene discussed is SIRT1; the disease is cyst.