PKD1 and cyst: Treatment of Pkd1 knockout mice with the CFTR regulator VX-809 (Lumacaftor) increased the localizations of CFTR in the basolateral membrane of cyst lining cells and those of the sodium proton exchanger 3 and the epithelial sodium channel in the apical membrane, thus promoting net resorption of cyst fluid, reducing cyst growth, and protecting kidney function (Yanda et al., 2018).