PTH and prion disease: The top three significant pathways for the 143 extremely DE genes were prion disease (hsa05020, adjusted P-value = 5.65 × 10-3), extracellular matrix–receptor interaction (hsa04512, adjusted P-value = 5.65 × 10-3), and parathyroid hormone synthesis, secretion, and action (hsa04928, adjusted P-value = 7.74 × 10-3) in the downregulated category (Figure 1D).