Loss of leptin receptor (LEPR) (21), autophagy-related 7 (ATG7) (22) or Protein Kinase C λ (PKCλ) (23) in POMC neurons cause glucose intolerance only in male mice, while loss of liver kinase B1 (LKB1) (24) or double deletion of LEPR and insulin receptor (IR) (25) in POMC neurons cause glucose intolerance only in female mice, regardless of the body weight change. This evidence concerns the gene INSR and Glucose intolerance.