In addition, LOX upregulation is also associated with anaplastic thyroid cancer progression and aggressive tall cell variant of PTC (TC-PTC) compared with the differentiated thyroid cancers [classic PTC (cPTC) and follicular variant of PTC (FV-PTC)] that may respond to BRAF activation (40–42). The gene discussed is LOX; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.