In conclusion, our outcomes show that vaccarin can reduce inflammatory injury by upregulating miR-570-3p thus inhibiting the increase of HDAC1 in the aorta of T2DM mice and HG-treated HUVEC cells (Figure 10), which provides new ideas, insights, and choices for the scope of application and medicinal value of vaccarin and some potential biomarkers or targets in diabetic endothelial dysfunction and vascular complications. Here, HDAC1 is linked to type 2 diabetes mellitus.