For example, down-regulation of HDAC1 can restore myocardial injury in septic mice to a certain extent (Nong, Qin et al., 2022), and ellagic acid can alleviate rheumatoid arthritis in rats by inhibiting HDAC1 (Song, Wu et al., 2021), and HDAC1 can control the metabolism of intestinal epithelial cells by regulating the supply of acetyl groups, resulting in impaired response to oxidative stress, AMPK kinase activation and mitochondrial biogenesis (Gonneaud, Turgeon et al., 2015). The gene discussed is HDAC1; the disease is rheumatoid arthritis.