First of all, vaccarin effectively reduced the blood glucose of T2DM mice (Figures 2C, D), improved glucose tolerance (Figures 2E, F), insulin tolerance (Figures 2G, H), a disorder of glucose and lipid metabolism, and physiological conditions of T2DM mice (Figures 2I–M), and also had a good effect on alleviating the inflammatory injury in the aorta of T2DM mice (Figures 3B–K). Here, INS is linked to type 2 diabetes mellitus.