Conditional knockout of ErbB2 in mice with accelerated heart failure after stress overload or adriamycin injury (Crone et al., 2002; Ozcelik et al., 2002) showed that the NRG/ErbB pathway acts as a stress response signal between microvascular endothelial cell and myocytes to maintain cell survival and cardiac function. This evidence concerns the gene EGFR and heart failure.