Data suggests that NRG1 significantly inhibits stress-induced premature senescence in vascular cells in vitro and in the aorta of diabetic mice in vivo (Shakeri et al., 2018), and application of rhNRG-1 for 9 weeks to type 1 diabetic mice attenuates diabetes-induced vascular senescence (Shakeri et al., 2018). The gene discussed is NRG1; the disease is diabetes mellitus.