NRG1 and diabetes mellitus: Consistently, deficiency of the NRG1 receptor ErbB4 induced cellular senescence both in vitro and in vivo (Shakeri et al., 2018), and diabetes induced significantly more vascular senescence in mice lacking the ErbB4 receptor in SMC compared to wild-type littermates (Shakeri et al., 2018), suggesting the efficacy of NRG1 in anti-cellular senescence.