Both celastrol and SHP2 inhibitors are involved in the regulation of T-cell function (Astry et al., 2015; Venkatesha et al., 2016), leading us to evaluate the effect of celastrol alone, SHP099 alone, and their combination on tumor immune infiltrates in MC-38 xenografts using IHC (Figure 6). Here, PTPN11 is linked to neoplasm.