TRPM8 and Sepsis: Indeed, the lack of in vitro studies that further explore the hepatoprotective effects of menthol in sepsis, the need to investigate the possible involvement of the menthol receptor (TRPM8) in preventing sepsis-associated complications and the elucidation of the main signaling pathways mediating the antioxidant effects of menthol are considered limitations of the present study that should be addressed in future studies.