In addition, by analyzing in human CRC tissue specimens obtained at the time of diagnosis (biopsy via colonoscopy) and surgery (surgical removal of CRC tissue), they demonstrated that CUR reduced the serum levels of TNF-α, induced apoptosis of CRC cells, upregulated p53 expression, and regulated the expression of apoptosis-related Bax and Bcl-2. This evidence concerns the gene TNF and colorectal carcinoma.