BCL2 and gastric cancer: Zhou et al. (2016) explored the synergistic antitumor effect of CUR and FOLFOX against GC in vitro and in vivo. Using cell proliferation assays and assessment of apoptosis, they demonstrated the synergistic antitumor effect of CUR in combination with 5-FU and OXA (5-FU/OXA). This effect may be associated with the downregulation of Bcl-2 expression and upregulation of Bax and CASP3/8/9 expression caused by CUR. In addition, the in vivo data showed that the combination of CUR and 5-FU/OXA significantly inhibited the growth of BGC-823 xenograft tumors.