AKT1 and cardiac hypertrophy: Resveratrol can downregulate immune proteasome activity and catalytic subunit (β-1i, β-2i and β-5i) induced by transverse aortic constriction (TAC) , inhibit phosphate and tension homology deleted on chromosome ten (PTEN) degradation, downregulate AKT/mTOR expression, and promote AMPK signal activation, so as to significantly inhibit myocardial hypertrophy, fibrosis and apoptosis and improve cardiac function (Chen et al., 2019).