Resveratrol can upregulate autophagy, downregulate oxidative stress and apoptosis through PI3K/AKT/mTOR pathway, significantly improve the ejection fraction of chronic intermittent hypoxia (CIH) rats, and inhibit myocardial hypertrophy and cardiac remodeling (Guan et al., 2019). This evidence concerns the gene MTOR and cardiac hypertrophy.