HMOX1 and myocardial ischemia: Then, it interacts with the transcription factor NRF2, upregulates the expression of heme oxygenase 1 (HO-1) and SOD1, promotes the production of antioxidant enzymes, and plays the role of anti-apoptosis and antioxidant, downregulates the apoptosis of cardiomyocytes caused by myocardial ischemia-reperfusion, and inhibits adverse cardiac remodeling (Wang et al., 2021).