↓ Heart weight; ↓ Heart weight/body weight ratio; ↓ LVEDD; ↓ LVESD; ↓ Myocardial fibrosis; ↓ Col I; ↓ Col III; ↑ SIRT1 mRNA; ↓ Ac-Smad3. The gene discussed is SIRT1; the disease is Myocardial fibrosis.