Through the study of infarcted myocardium, it is found that the upregulated stem cell factor (SCF) (Frangogiannis et al., 1998b) and the increase of pressure load may promote mast cell aggregation, induce myocardial fibrosis and participate in cardiac remodeling (Levick et al., 2009). The gene discussed is KITLG; the disease is Myocardial fibrosis.