AGT and Myocardial fibrosis: Resveratrol can downregulate ERK 1/2 induced by basal cells and Ang II, and inhibit cardiac fibroblasts (CFs) growth, proliferation and differentiation into myofibroblast phenotype induced by Ang II and TGF-β, which have concentration-dependent characteristics, and resveratrol plays a vital role in inhibiting myocardial fibrosis and cardiac remodeling (Olson et al., 2005) (Figure 4).