Taken together, RAB6B, which may be highly expressed in CD8+ T cells, participated in the regulation of CD8+T cells exhaustion by up-regulating the expression of immune checkpoint molecules, the secretion of immunosuppressive cytokines, and the recruitment of various immunosuppressive cells into HCC, thereby creating an immunosuppressive tumor microenvironment in HCC. This evidence concerns the gene RAB6B and neoplasm.