CD8A and hepatocellular carcinoma: Taken together, RAB6B, which may be highly expressed in CD8+ T cells, participated in the regulation of CD8+T cells exhaustion by up-regulating the expression of immune checkpoint molecules, the secretion of immunosuppressive cytokines, and the recruitment of various immunosuppressive cells into HCC, thereby creating an immunosuppressive tumor microenvironment in HCC.