Nonetheless, the present study surprisingly found that PDTC treatment only rescued partial features of liver fibrosis, namely the increase in the ALT and AST activities, and α-SMA expression, in CKO mice with CCl4 treatment, while HYP activity and collagen I and III levels showed no statistically significant difference in these mice after PDTC treatment. The gene discussed is ACTA1; the disease is Hepatic fibrosis.