Intriguingly, one of the remarkable findings of the present study was that SM934 had a robust effect against pyroptosis not only repressing the pyroptosis-associated gene transcription levels but also preventing the apoptosis-associated proteins of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-18, and HMGB1 in the colon tissues of colitis mice (Figure 5). This evidence concerns the gene HMGB1 and colitis.