IL18 and inflammatory bowel disease: Then, mature GSDMD causes features like cell membrane-located pore formation, cell swelling, and rupture, which ultimately leads to cell pyroptosis, as well as the following releases of pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) that occur in intestinal tissues to modulate the epithelial barrier function and mediate the inflammatory response in the progression of IBD (Kim and Kim, 2018; Liu et al., 2018).