In spite of this, SM934 regulated the balanced Bcl-2 and BAX, and cleaved caspase-9 and cleaved caspase-3 in colitis (Figure 3), and also downregulated the cleaved caspase-3 in TNF-α-induced IEC apoptosis in vitro (Figures 4F–H). The gene discussed is BCL2; the disease is colitis.