For example, the combination of anti-PD-L1 and anti-IL-6 antibodies increases IFN-γ and Th1 in melanoma mice (Tsukamoto et al., 2018), turning off IL-6/STAT3 pathway, which further activates IFN-γ/STAT1 for causing local inflammation (Xiang et al., 2020). The gene discussed is CD274; the disease is melanoma.