On the other hand, IL in tumor cells can also cause high PD-L1, like IL-4, IL-17 in prostate and colon cancer cells (Wang et al., 2017), IL-27 in ovarian cancer cells (Carbotti et al., 2015), IL-10 in myelodysplastic syndrome blasts (Kondo et al., 2010), renal cell carcinoma (Quandt et al., 2014). This evidence concerns the gene CD274 and neoplasm.