Various mechanisms have been reported to be involved in the development of MDR in tumor cells, including ATP-binding cassette (ABC) transporter family-mediated drug efflux, apoptosis down-regulation and epigenetic regulation, etc., of which the ABC transporter family is the most widely studied (Abraham et al., 2009; Rocha et al., 2018; Assaraf et al., 2019; Bukowski et al., 2020). This evidence concerns the gene ABCG2 and neoplasm.