It has been found that the ABC transporters could bind and transport chemotherapeutic drugs outside the cell by utilizing the energy provided by ATP hydrolysis, resulting in lowering the concentration of intracellular drug accumulation, reducing the efficacy of chemotherapeutic drugs and the failure of tumor treatment (Amawi et al., 2019; Liu, 2019; Eckenstaler and Benndorf, 2020). Here, ABCG2 is linked to neoplasm.