TNF and Mycoplasma pneumoniae pneumonia: One in vitro study of MGD on serum of children with Mycoplasma pneumonia also showed that MGD suppressed L-1β, IL-18, TNF-α, down-regulated NLRP3, pro-IL-1β, Caspase-1, pro-Caspase-1, and GSDMD-N in infected cultures and mitigated NLRP3 overexpression-induced pyroptosis (Liu et al., 2021).