TNF and Mycoplasma pneumoniae pneumonia: were effective Chinese medicines for the treatment of mycoplasma pneumonia; further analysis of 93 active ingredients in Chinese medicines revealed that TNF, β2AR and PTGS2 played a key role in the anti-pneumonia, and epithelial cell apoptosis (defensive barrier function), GPCR signal transduction (improvement of symptoms) and immune pathways (innate Signal transduction and adaptive Th17 response) were important therapeutic mechanisms (Sun et al., 2020a).