A HIF-1α-mediated switching to glycolysis was observed in rodent models of DKD, proximal tubules, mesangial cells, and macrophages under HG conditions and proved to play a pivotal role in the fibrosis process of DKD by inducing inflammation, lipid accumulation, and the EMT (Matoba et al., 2013; Nayak et al., 2016; Bessho et al., 2019). The gene discussed is HIF1A; the disease is diabetic kidney disease.