Prior studies have suggested that inhibition of Nox4 reduced oxidative stress and lung injury caused by various diseases or conditions such as sepsis (Jiang et al., 2020), ischemia-reperfusion (Cui et al., 2018), influenza A virus infection (Yu et al., 2020) and paraquat poisoning (Liu et al., 2019), suggesting Nox4 inhibition exerts protective effects against lung injury. The gene discussed is NOX4; the disease is Sepsis.