During HIV-1 infection, WKYMVm desensitizes HIV-1 coreceptors C-C motif chemokine receptor 5 (CCR5) and C-X-C motif chemokine receptor 4 (CXCR4) on the surface of monocytes by activating FPR2, thereby effectively inhibiting HIV-1 Env-mediated fusion and viral infection. Here, CXCR4 is linked to viral infectious disease.