AKT1 and Insulin resistance: By activating FPR2, WKYMVm can ameliorate insulin resistance by sensitizing the insulin pathway in metabolic tissues (skeletal muscle and liver) of high-fat diet (HFD) mice and palmitate-induced insulin resistance models in L6 myotubes, including increasing insulin-stimulated Akt (S473) phosphorylation, inhibiting the phosphorylation of PKC-θ (T538) and insulin receptor substrate 1 (IRS1) (S307), and reducing IL-6 expression (Yoon et al., 2015).