A study pointed out that YTHDC2 was markedly downregulated in the livers of obese mice and NAFLD patients and its overexpression in the livers of obese mice improved liver steatosis (Zhou et al., 2021), which was consistent with our results that YTHDC2 expression decreased in NAFLD and was related to steatosis. Here, YTHDC2 is linked to fatty liver disease.