As shown in Figure 1A, compared with the controls, the expressions of m6A regulators increased significantly (p < 0.05), including METTL3 (logFC = 0.237), METTL14 (logFC = 0.377), FTO (logFC = 0.300), and EIF3H (logFC = 0.193), while some other m6A regulators significantly decreased, including WTAP (logFC =− 0.385), RBM15 (logFC =− 0.396), YTHDC1 (logFC =− 0.172), YTHDC2 (logFC =− 0.148), IGF2BP2 (logFC =− 0.514), HNRNPC (logFC =− 0.209), and HNRNPA2B1 (logFC =− 0.414) in NAFLD. The gene discussed is METTL3; the disease is metabolic dysfunction-associated steatotic liver disease.