Michalinos et al. (2020) found that Gpnmb was upregulated in the liver and kidneys following hepatic damage, but after treatment with hepatoprotective drugs, its expression was significantly decreased. Similar to the preceding outcomes, in this work, we observed that HSYA could drastically reduce the hepatic expression levels of Gpnmb in rats with CCl4-induced ALI, suggesting that this gene may be a potential target for intervention in ALI. The gene discussed is GPNMB; the disease is acute respiratory distress syndrome.