For this study, a crosslinked multilamellar liposomal vesicle was developed to carry phenelzine (cMLV-PLZ), which has been demonstrated to elicit powerful antitumor responses by increasing autocrine serotonin signaling in CD8+ T cells, as an alternative delivery system that would limit its systemic administration and improve its delivery to tumor-infiltrating immune cells (Benadiba and Maor, 2016; Wang et al., 2021a). This evidence concerns the gene CD8A and neoplasm.