NFKB1 and arthritic joint disease: Nuclear factor-kappa B(NF-κB) is a protein complex responsible for DNA transcription, cytokine secretion, and cell survival (Wu et al., 2016), and its abnormal signaling pathway is associated with some chronic inflammatory diseases such as inflammatory bowel disease, sepsis, arthritis, and atherosclerosis (Theofilis et al., 2021).