The central new, and in two CRC cell lines reproducible, insights gained within our study were: 1) resveratrol uses β1-integrin receptors to shift the balance from mesenchymal to epithelial morphology in CRC cells; 2) resveratrol uses β1-integrin receptors to down-regulate invasion as well as metastasis of CRC cells; 3) furthermore, resveratrol uses β1-integrin receptors to suppress inflammation in CRC cells; 4) and finally, resveratrol synergistically amplifies NF-κB knockdown, thereby increasing the anti-inflammatory effect on CRC cells. The gene discussed is NFKB1; the disease is colorectal carcinoma.