Contrarily, in CRC cultures with β1-integrin knockdown (0.5 μM β1-ASO), no suppression of CXCR4, phosphorylated FAK and phosphorylated NF-κB could be observed by resveratrol co-treatment (5 μM) so that their expression pattern resembled the TME control (Figure 6). This evidence concerns the gene CXCR4 and colorectal carcinoma.