CASP3 and colorectal carcinoma: Also in this regard, resveratrol showed a major modulatory effect by significantly increasing caspase-3 levels in a concentration-dependent (1, 5 μM) manner, both in TME-CRC cells and in β1-SO-treated (0.5 μM) TME-CRC cells, which was inhibited by β1-integrin knockdown (0.5 μM β1-ASO), visible by very low caspase-3 expression.