Investigations on CRC primary tumors showed that they were prone to have a dedifferentiated, mesenchymal phenotype, a noticeably reduced E-cadherin expression, an increased paxillin expression, and a high tendency to metastasize (Kaihara et al., 2003; Buhrmann et al., 2015; Wen et al., 2020). The gene discussed is PXN; the disease is colorectal carcinoma.