The aforementioned hallmarks of CRC progression, EMT and metastasis, are promoted by chronic inflammatory processes (Vuletić et al., 2021) indicating the great importance of NF-κB, which is considered a major inflammatory and tumorigenesis marker (Ko et al., 2017) in its phosphorylated, thereby activated form. This evidence concerns the gene NFKB1 and colorectal carcinoma.