Furthermore, resveratrol, as a multi-target molecule has been reported to interfere and negatively affect NF-κB signaling pathways, which is one of the major inflammatory transcription factors and markers promoted by the TME, that was shown to affect invasion behavior matrix metallopeptidase 9 (MMP-9) and metastasis process chemokine receptor type 4 (CXCR4) in CRC cells (Bergman et al., 2013; Buhrmann et al., 2016; Suh et al., 2018; Buhrmann et al., 2020). Here, NFKB1 is linked to colorectal carcinoma.