The aim of our study was to determine the role of β1-integrin receptors in the anti-invasive, anti-metastatic and anti-inflammatory effects of resveratrol in two CRC cell lines (HCT116, RKO) in a pro-inflammatory, multicellular, in vivo-like tumor microenvironment in vitro by β1-integrin knockdown and NF-κB knockdown via antisense oligonucleotides (ASO). This evidence concerns the gene NFKB1 and neoplasm.