CXCR4 and colorectal carcinoma: Moreover, resveratrol treatment alone was able to down-regulate the metastasis-related factors including FAK, of which cascade activation is known to be integrin-dependent (Lipfert et al., 1992; Cheng et al., 2021) as well as CXCR4, shown to up-regulate αvβ6-integrin in CRC cells, thus promoting metastasis (Wang et al., 2014).