Specifically for colorectal carcinoma, α1-integrin has already been shown to be associated with increased tumorigenesis, CRC cell migration and invasion (Li et al., 2020), and β6-integrin provided even more accurate prognosis than the already established tumor marker carcinoembryonic antigen (CEA) for tumor surveillance of patients with advanced CRC stage (Bengs et al., 2019). This evidence concerns the gene CEACAM5 and neoplasm.