HCC correlates with ubiquitination of METTL3, METTL3 SUMOylation was increased in HCC, and the UBC9/SUMOylated METTL3/Snail axis is a novel mediator of sumoylation (SUMO) pathway involvement in HCC progression (Xu et al., 2020). The gene discussed is UBE2I; the disease is hepatocellular carcinoma.