HIF-1α-regulated YTHDF1 expression enhanced the translation of autophagy-associated 2A (ATG2A) and 14 (ATG14) in an m6A-dependent manner to drive hypoxia-induced HCC autophagy It was shown that radiofrequency ablation (IRFA)-deficient sublethal heat stress promotes HCC progression by upregulating EGFR expression levels through an N6-methyladenosine mRNA methylation-dependent mechanism (Su et al., 2021). Here, YTHDF1 is linked to hepatocellular carcinoma.