ALKBH5 and hepatocellular carcinoma: ALKBH5 mediates circular cleavage and polyadenylation-specific factor 6 (circCPSF6) demethylation, promoting the malignant development of HCC through aberrant activation of the circCPSF6 and Yes1 associated transcriptional regulator (YAP1) axis, providing new insights into the regulation of circRNAs by m6A modification together with epigenetic reprogramming in HCC (Chen et al., 2022).