Additionally, METTL14-mediated m6A modification maintains sirtuin 6 (SIRT6) stability by regulating the expression of ubiquitin-specific peptidase 48 (USP48) and promoting the tumor suppressive function of glycolysis to regulate the metabolic activity of HCC (Du et al., 2021). This evidence concerns the gene SIRT6 and hepatocellular carcinoma.