The METTL3/IGF2BP1 complex enhanced the stability of NIFK-AS1 mRNA by increasing the expression level of m6A, promoted the growth and invasion of HCC cells, and promoted the progression of HCC through the AKT1-MMP7/9 axis (Chen et al., 2021d). This evidence concerns the gene IGF2BP1 and hepatocellular carcinoma.