Microwave ablation is a therapeutic approach for HCC, and studies have shown that sublethal heat treatment promotes HCC migration and EMT transformation through induction of METTL3 and CD47, that METTL3 mediates HCC migration through CD47 in an m 6 A-dependent manner, and that the METTL3/IGF2BP1/CD47 axis is a target for potential treatment by microwave ablation, providing clues to the link between RNA methylation and incomplete thermal ablation (Fan et al., 2021a). This evidence concerns the gene IGF2BP1 and hepatocellular carcinoma.