In addition, METTL3-mediated m6A modification down-regulates the expression level of maternally expressed 3 (MEG3), which targets miRNA 544b (miR-544b), miR-544b promotes HCC proliferation, invasion, and metastasis by suppressing BTG2 expression (Wu et al., 2021b). Here, MEG3 is linked to hepatocellular carcinoma.