IGF2BP1 promotes the translation of circRNA MAP3K4 (circMAP3K4) into circMAP3K4-455aa, inhibiting allograft inflammatory factor 1 (AIF1) cleavage and nuclear distribution, preventing cisplatin-induced apoptosis, and promoting HCC progression (Duan et al., 2022). This evidence concerns the gene IGF2BP1 and hepatocellular carcinoma.