It was also shown that lysine demethylase 5B (KDM5B) regulates the axis formed by YTHDF3 and integrin subunit alpha 6 (ITGA6) axis by suppressing miRNA 448 (miR-448) expression and promoting HCC progression (Guo et al., 2021). This evidence concerns the gene ITGA6 and hepatocellular carcinoma.