As for IMI, β-HgS enhanced its effects in preventing atrophy and severe structural damage in the hippocampus, promoting GR and neuronal proliferation levels in key hippocampal subregions and increasing serum IL-10 and SOD levels, whereas β-HgS did not significantly enhance the ameliorating effect of IMI on depression-like behavior in stress-stimulated mice. Here, SOD1 is linked to major depressive disorder.