Persistent hyperglycemia of diabetes can also disrupt mitochondria by increasing dynamin-related protein 1 (DRP1) expression (Ding et al., 2017), blocking the mitochondrial KATP channel (Li et al., 2013), and inactivating hypoxia-inducible factor-1 (HIF-1α) (Riquelme et al., 2016). This evidence concerns the gene DNM1L and diabetes mellitus.