As shown in Figures 7C–E, NAY successfully restored the overexpression of the renal NLRP3 inflammasome component in hyperuricemia mice induced by potassium oxonate (10 mg/kg: ASC and NLRP3, p < 0.01, Caspase-1, p < 0.05; 20 mg/kg: ASC and Caspase-1, p < 0.001, NLRP3, p < 0.05; 40 mg/kg: SC and Caspase-1, p < 0.001, NLRP3, p < 0.05). This evidence concerns the gene CASP1 and hyperuricemia.