In Figures 12C–E, the protein expression levels of ASC, Caspase-1, and NLRP3 in adenosine-induced hyperuricemia HK-2 cells were higher than those in the blank control group (p < 0.05), and NAY can alleviate the overexpression of ASC, Caspase-1, and NLRP3 proteins (50 μmol/L: Caspase-1, p < 0.01; 100 μmol/L: ASC, p < 0.05, NLRP3 and Caspase-1, p < 0.01; 200 μmol/L: ASC, p < 0.05, NLRP3 and Caspase-1, p < 0.001). The gene discussed is CASP1; the disease is hyperuricemia.