GABAARα1, GABAARγ2, GABABR1, and GAD67 protein expression levels were significantly increased (p < 0.001, p < 0.01), whereas GAT-1 and NR2B protein expression levels were significantly decreased in the hippocampus and prefrontal cortex regions of rats with CF (p < 0.01). The gene discussed is SLC6A1; the disease is cystic fibrosis.