Oncolytic measles, reovirus vectors, and recombinant nonpathogenic polio rhinovirus (PVS-RIPO) are reoviruses that only replicate in glioma cells because platelet-derived growth factor receptor (PDGFR) or EGFR stimulation of the KRAS pathway suppresses ribonucleic acid (RNA)-activated protein kinase activation. Here, KRAS is linked to central nervous system cancer.