Our systematic review showed that COVID-19 patients with pericarditis exhibited leukocytosis with neutrophil predominance, elevated inflammatory markers (ESR and CRP), and elevated D-dimer levers as well. These case studies also exhibited elevated cardiac markers (troponin-I, troponin-T, CK-MB, and BNP) as well. Typically, 32-50% of cases of viral and idiopathic acute pericarditis as evidence of inflammatory myocardial damage and possible evidence of myopericarditis [47]. This evidence concerns the gene CRP and COVID-19.