Based on the fact that PSGs enhanced IL-10 production among myeloid cells, coupled with the known links between Tregs and microglia in post-stroke repair, a more complex mechanism involving modulation of microglia phenotype by rPSG1-Fc is also possible (Motrán et al., 2003; Ha et al., 2005; Xie et al., 2014; Cai et al., 2020). The gene discussed is IL10; the disease is Stroke.