But while the absence of drug-induced lymphopenia would reduce the risk of treatment-associated infection, it should be recognised that pregnancy itself is associated with increased risks for certain types of infections, and that the immunological changes behind this trend (e.g., increased Treg-derived IL-10) could be conferred by rPSG1-Fc treatment (Houston et al., 2016; Zhang et al., 2021; Abu-Raya et al., 2020; Rowe et al., 2011). Here, IL10 is linked to lymphopenia.