These protein molecules are mainly enriched in complement and coagulation cascade, platelet activation, Rap1 signaling, neuroactive ligand-receptor interaction, modulation of actin cytoskeleton, cancer pathway, phospholipase D signaling, PI3K/AKT signaling pathway, etc. PI3K/AKT is a typical signaling pathway that modulates cell growth, metastasis, apoptosis, and drug resistance. Here, PIK3CA is linked to cancer.