Important evidence of a link between IL-6 and cardiovascular disease has indicated that the Asp358Ala (rs2228145, formerly known as rs8192284) variant in IL6R might impair classic IL-6R signaling and hence dampen inflammation, and other human genetic factors support a causal association between IL-6R-related pathways and coronary heart disease (41–44). This evidence concerns the gene IL6 and cardiovascular disorder.