The study will be conducted in various countries and regions, including the United States, Brazil, Japan, India, Russia, Puerto Rico, and Taiwan, and it is planned to include a sample size of approximately 900 patients to explore the efficacy and safety of TZP for the treatment of patients with obese or overweight with T2DM when measured by weight, BMI, waist circumference, HbA1c, FSG, lipids, blood pressure, and fasting insulin. This evidence concerns the gene INS and type 2 diabetes mellitus.