INS and type 2 diabetes mellitus: The meta-analyses published by Karagiannis et al. (20) and Bhagavathula et al. (21) compared the efficacy and safety of TZP with placebo, insulin and GLP-1 RA in the treatment of T2DM, which confirmed that the hypoglycemic effect of TZP was significantly better than that of placebo, insulin and GLP-1RA.