Meta-analyses published by Karagiannis et al. (20) and Bhagavathula et al. (21) comparing the efficacy and safety of TZP with placebo, insulin and GLP-1 RA for the treatment of T2DM confirmed that TZP was significantly more effective in lowering glycemia than placebo, insulin and GLP-1RA. This evidence concerns the gene INS and type 2 diabetes mellitus.