AGT and endothelial dysfunction: In turn, Siedlinski et al. revealed that angiotensin II (AngII)-induced hypertension is associated with increased plasma concentrations of S1P in wild type (C57BL/6J) mice and chronic infusion of S1P caused a moderate, increase in systolic blood pressure, endothelial dysfunction, and vascular contractility in the mesenteric arteries (34).