SPP1 and Hypercalcemia: In addition, the same researchers showed that high doses of vitamin D-induced hypercalcemia in Smpd1trg/SMcre mice with overexpressing the acid lysosomal sphingomyelinase (SMPD1) gene specific for aortic and coronary smooth muscle cells contributed to higher aortic and coronary AMC as well as increased expression of RUNX2 and osteopontin in the coronary and aortic media (58).