Administration of fingolimod (FTY720), which is a non-selective S1PR1, 3, 4, 5 agonist, increased the blood pressure in normotensive C57BL/6 mice and exacerbates hypertension in AngII mouse model, underlining the antihypertensive function of S1PR1 signaling (35, 43). This evidence concerns the gene S1PR1 and hypertensive disorder.