APOE and atherosclerosis: Skoura et al. (66) have shown that ApoE and S1PR2-deficient Apoe-/-S1pr2-/-mice show reduced development of western diet-induced atherosclerosis, present decreased fibrous tissue, collagen and lipid content, as well as decreased necrotic core within the atherosclerotic plaque and a reduced number of macrophages within the vessel wall in comparison with the Apoe-/-S1pr2 + / + controls.