SMPD2 and myocardial infarction: In addition, myocardial concentrations of Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), and Cer(d18:1/24:0), as well as the expression of serine palmitoyl transferase-2 (the gene encoding a base subunit of SPT), ceramide synthase 6 (CerS6), and neutral sphingomyelinase (nSMase) were found to be significantly higher in Wistar rats with acute MI induced by LAD occlusion in comparison with the sham-operated control group (138).