IL1B and diabetes mellitus: Yuan et al. (56) showed that endothelium-specific AC gene knockout mic (Asah1fl/fl/ECcre) with streptozotocin-induced diabetes significantly augmented the production and activation of NOD-like receptor pyrin domain 3 (NLRP3) inflammasomes in the coronary artery endothelial cells, as well as significantly higher expression of exosome markers auch as CD63 and alkaline phosphatase (ALP) in the coronary arterial wall and interleukin 1 beta (IL-1β) release of exosomes in comparison with wild-type (WT/WT) littermates.