On the other hand, Guanbataar et al. showed that ApoE-deficient mice receiving a S1PR2 antagonist and fed on a western-type diet resulted in the reduction of atherosclerotic plaque development, and alleviated endothelial dysfunction as well as resulting in significantly decreased lipid deposition, macrophage accumulation, and the expression of inflammatory proteins within the aorta (67). Here, APOE is linked to endothelial dysfunction.