The high percentage of indirect hyperbilirubinemia in the Bahraini population may be attributed to the high prevalence of G6PD deficiency, as 46.1% of Bahraini nationals were G6PD deficient, while it affected 3.1% of the non-Bahraini population in this study (P < 0.0001). The gene discussed is G6PD; the disease is G6PD deficiency.