In terms of such a challenging condition, a few reports have shown the potency of molecular targeted therapy, EGFR-TKI as a novel strategy for the treatment of cases with multiple GGNs, and they helped provide a non-invasive therapeutic approach for EGFR-mutated lung adenocarcinoma manifesting as pGGN (12, 13). This evidence concerns the gene EGFR and lung adenocarcinoma.