Dysadherin protein was immunohistochemically observed on cancer cell membranes, but not in the normal epithelium in colorectal carcinoma (n=82 and n=123, 2 studies), gastric cancer (n=276), pancreatic ductal adenocarcinoma (PDAC, n=125) and extrahepatic cholangiocarcinoma (100 ECC, 30 peritumoral tissues, 10 adenoma, 15 normal biliary tract tissues) (14, 15, 17–19). The gene discussed is FXYD5; the disease is colorectal carcinoma.