Recently, it has been reported that retinoic acid receptor-related orphan receptor α (ROR α) (40), Achaete scute-like 2 (ASCL2) (41) and DNA inhibitor binding/differentiation 2 (Id2) (42) bind the promoter region of SEMA3F in colon cancer. This evidence concerns the gene SEMA3F and malignant colon neoplasm.