CD8A and hepatocellular carcinoma: Hepatic receptor-interacting protein kinase 3 (RIP3) defect stimulates chemokine (CXC motif) ligand 1 (CXCL1)/chemokine (CXC motif) receptor 2 (CXCR2)–induced MDSC recruitment and decreases IFN+ CD8+ T-cell infiltration, thereby facilitating immune escape and HCC progression (62).