The following were the most common TRAEs: thrombocytopenia (32.7%), elevated aspartate aminotransferase (AST) levels (28.2%), elevated alanine aminotransferase (ALT) levels (24.5%), diarrhea (23.7%), elevated thyroid-stimulating hormone (TSH) levels (22.7%), proteinuria (21.8%), hypothyroidism (20.0%), hyperlipidemia (19.1%), anemia (18.2%), leukopenia (16.4%), hypertension (15.5%), hand-foot syndrome (14.5%), elevated lactate dehydrogenase levels (14.5%), constipation (12.7%), nausea or vomiting (11.8%), and elevated bilirubin levels (10.9%). The gene discussed is GPT; the disease is hypothyroidism.