Subsequently, multivariate approach revealed that HBV DNA levels ≥2,000 IU/ml, IL-25 ≥ 14.9 μg/ml, AFP ≥ 20 ng/ml, a lack of complete encapsulation of tumor, multiple tumors, microvascular invasion, and tumor size ≥ 5 cm were independent predictors of worse patient RFS (Table 4), while HBV DNA levels ≥ 2,000 IU/ml, IL-25 ≥ 14.9 μg/L, AFP ≥ 20 ng/ml, a lack of complete tumor encapsulation, and tumor size ≥ 5 cm were independently predictive of worse OS (Table 5). This evidence concerns the gene AFP and neoplasm.