LOXL4 and colorectal cancer: The accumulation of lysyl oxidase like 4 (LOXL-4)-expressing neutrophils in colorectal cancer lung metastases with replacement growth pattern, where VCO is the dominant pattern of vascularization, suggested their possible role in supporting the growth of vessel co-opted tumors, and indicated them as potential targets to control VCO (112) (Figure 1, Figure 6E).