PLG and cancer: Moreover, when low and highly invasive breast cancer cells (MDA231 vs. MDA231-BrM) and lung adenocarcinoma cells (H2030 vs. H2030-BrM) were seeded onto brain slices, low-invasive brain parental cancer cells succumbed via serpin- and plasmin-dependent pathways, whereas brain invasive BrM cells moved towards and disseminated over brain capillaries (20).