Furthermore, VEGF inhibition, in addition to increasing MET levels, leads to enrichment of hypoxia-associated markers (including HIF1α (Figure 5), carbonic anhydrase 9 (CA9) and GLUT1), as well as downregulation of epithelial adherens junction proteins T-cadherin and E-cadherin, thus creating more mesenchymal, invasive cancer cells (85). Here, VEGFA is linked to cancer.