Considering the 9 BC-genes, which were recently described as the most relevant BC predisposing genes (BRCA1, BRCA2, ATM, BARD1, CHEK2, PALB2, RAD51C, RAD51D and TP53) (9), 16.8% patients were detected as carriers GPV in at least one of these genes. The gene discussed is CHEK2; the disease is breast cancer.