We evaluated potential associations among clinical variants and the BC carriers with GPVs in both BRCA1 and BRCA2 genes, and 22 additional genes (ATM, BLM, BRIP1, CHEK2, FANCA, FANCD2, FANCE, FANCI, FANCL, FANCM, FH, HNF1A, MUTYH, PALB2, PHOX2B, PMS2, PRF1, RAD51C, RECQL4, SBDS, SLX4 and TP53). The gene discussed is SLX4; the disease is breast cancer.