GPVs in genes of high-penetrance for BC were found in 39 patients (12.15% - 39/321) including: 17 (5.3%) in BRCA1; 14 in BRCA2 (4.3%); 4 in TP53 (1.2%) and 4 in PALB2 (1.2%), corresponding to 47% (39/83) of the positive results. This evidence concerns the gene BRCA2 and breast cancer.