A phase II trial (DOVIGIST, NCT01478373) evaluated the antitumor activity of dovitinib as a second-line therapy in patients with GIST who were refractory to or intolerant of imatinib, including a total of 38 patients, of which 21 patients had KIT mutations and three patients had PDGFRA mutations. This evidence concerns the gene KIT and gastrointestinal stromal tumor.