Around 15% of GISTs are wild-type GIST, which have no mutations in either KIT or PDGFRA, but have other genetic alterations, such as in the succinate dehydrogenase (SDH) gene family, RAS gene family, proto-oncogene B-Raf (BRAF), neurofibromatosis type 1 (NF1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), gene fusions involving ETS variant transcription factor 6 (ETV6)-neurotrophic tyrosine receptor kinase 3 (NTRK3) or fibroblast growth factor receptor 1 (FGFR1), or other rare driver gene mutations (10–13). The gene discussed is PIK3CA; the disease is gastrointestinal stromal tumor.