Importantly, this adaptive phenotypic transition of melanoma cells towards a dedifferentiated state, associated with upregulated expression of genes involved in EMT, ECM reprogramming, wound healing, cytoskeletal remodeling and YAP/TAZ/TEAD signatures has also been linked to immune evasion and resistance to PD-1 blockade immunotherapy (67, 68). This evidence concerns the gene PDCD1 and melanoma.