Matrices derived from dedifferentiated, melanoma cells were found to be enriched for key ECM structural proteins (e.g., fibronectin, laminin, collagen I, collagen IV, collagen VIII, tenascin) and proteins involved in ECM remodeling processes (e.g., Thrombospondin-1, Lysyl oxidase homolog 2 (LOXL2), ADAMTS-like protein 1 and Plasminogen activator inhibitor 1) (14). This evidence concerns the gene FN1 and melanoma.